Understanding the role of Rho GTPase Rac1 in signaling pathways using antioxidants.

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Understanding the role of Rho GTPase Rac1 in signaling pathways using antioxidants.

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Title: Understanding the role of Rho GTPase Rac1 in signaling pathways using antioxidants.
Author: Kirmani, Deeba (Scholar); Zargar, Mohd Afzal (Guide); Khanday, Firdous A. (Co-Guide)
Abstract: Antioxidants are intimately involved in the prevention of cellular damage, the common pathway for cancer, aging, and a variety of diseases. Antioxidants are molecules, which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. Although there are several enzyme systems within the body that scavenge free radicals, the principle micronutrient antioxidants are vitamin E, beta-carotene, and vitamin C. Additionally, selenium, a trace metal that is required for proper function of one of the body's antioxidant enzyme systems, is sometimes included in this category. The body cannot manufacture these micronutrients so they must be supplied in the diet. Antioxidant is capable of slowing or preventing the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent. Oxidation reactions can produce free radicals, which start chain reactions that damage cells. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions by being oxidized themselves. As a result, antioxidants are often reducing agents such as thiols or polyphenols. Although oxidation reactions are crucial for life, they can also be damaging; hence, plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, Vitamin C, and vitamin E as well as enzymes such as catalase, super oxide dismutase and various peroxidases. Low levels of antioxidants, or inhibition of the antioxidant enzymes, causes oxidative stress and may damage or kill cells. As oxidative stress might be an important part of many human diseases, the use of antioxidants in pharmacology is intensively studied, particularly as treatments for stroke and neurodegenerative diseases. However, it is unknown whether oxidative stress is the cause or the consequence of disease.
Description: Digital copy of Thesis.
URI: http://dspaces.uok.edu.in/jspui//handle/1/1651
Date: 2016-01-19


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