Role of pre-operative chemotherapy in non small cell carcinoma lung; a comparative study.

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Role of pre-operative chemotherapy in non small cell carcinoma lung; a comparative study.

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Title: Role of pre-operative chemotherapy in non small cell carcinoma lung; a comparative study.
Author: Raj Kumar (Scholar); Lone, G. N (Guide); Sheikh, Aejaz Aziz (Guide); Teli, M. Ashraf (Guide); Gojwari, Tariq A. (Guide)
Abstract: Background: Lung Cancer remains the most common malignancy killing more people every year than breast, colon and prostate cancers in combine together. It is also the most preventable cancer with more than 80% of cases associated with smoking. In Kashmir more than 150 new cases per year are registered. The use of systemic therapy before definitive local therapy referred to as induction or neo adjuvant therapy aims to prevent the growth of systemic disease, shrink the loco regional macroscopic disease and early eradication of micro metastasis. Objectives: To evaluate the efficacy of preoperative chemotherapy based on cisplatin and paclitaxel in patients with stage IIA –IIIA non small cell cancer with regard to 1) Local tumor control, 2) Overall impact on disease free survival, and 3) Immediate and delayed toxicity due to treatment. Materials & Methods: the present case control study was conducted jointly in the Department of CVTS, Medical Oncology, Radiotherapy and Radio diagnosis of SKIMS The study was conducted over a period of 2 years and included study of 50 cases (Nov 2006 to Dec 2008). Results: The male to female ratio was 5.2: 1, in study group and 7.3:1 in control group. and the age range was 35-70yrs. Chest pain was the main presenting feature in 76% in study and 80% in control group of patients followed by cough in 68% in study group and 76% in control group. Bronchoscopy and CECT Chest was performed in all cases for staging the patient. In 4 cases we had complete response.16 patients had shown partial response and in 4 patients the disease remained static. The overall response rate was 80%. Conclusions: The pre operative chemotherapy is well tolerated and significantly increases the rate of resectibility.
URI: http://dspaces.uok.edu.in/handle/1/762
Date: 2009


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