Primary gastrointestinal lymphomas – a histopathological and immunohistochemical study.

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Primary gastrointestinal lymphomas – a histopathological and immunohistochemical study.

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Title: Primary gastrointestinal lymphomas – a histopathological and immunohistochemical study.
Author: Qadri, S. K. (Scholar); Shah, A (Guide); Baba, Khalil (Guide)
Abstract: Research Question: Does the pathological profile of Primary Gastrointestinal Lymphomas (PGL) in our set up differ from that in the rest of the world? Objectives: 1) To study the pathology of PGL; 2) To identify the number and the anatomical location of PGL cases seen over a defined period; and 3) To classify lymphomas histopathologically and immunohistochemically. Study Design & Settings: Prospective & retrospective, 10 year, hospital based study. Materials & Methods: A total of 50 cases of PGL diagnosed as per the Dawson’s criteria, received in the Department over a period of 10 years were studied. Biopsies were received in 15 cases (30%) and resected surgical specimens in 35 cases (70%). Only prospective cases (11) were subjected to IHC. Results: The lymphomas occurred predominantly in the middle-aged and elderly with maximum patients presenting in their 5th decade. The incidence of lymphomas in males was about three times the incidence in females (M:F, 2.8:1). Overall, the distribution of lymphomas was as follows: small intestine (36%), large intestine (32%), stomach (28%) and multifocal (4%). Ileum was the most common (22%) site followed by cecum (18%) and the body of stomach (14%). Gross pathology of the cases was as follows: Ulcerative/Ulceroinfiltrative (52%), Proliferative/tumorous mass (42%) and Diffuse/ Infiltrative lesions (6%). histopathologically, except one case of Hodgkins lymphoma, all cases were non-Hodgkins lymphomas (98%). Following subtypes of non-Hodgkins lymphomas were identified: Diffuse large cell lymphoma (81.6%), MALT lymphoma (14.28%) and IPSID (4.08%). All the prospective cases that were subjected to IHC were positive for B-cell markers. Conclusions: Small intestine is the most common site of PGL followed by large intestine and stomach, in our set up. Most of these are non-Hodgkins lymphomas with diffuse large cell lymphoma followed by MALT lymphoma, the most common subtypes. B-cell lymphomas are the predominant type of primary gastrointestinal Lymphomas.
URI: http://dspaces.uok.edu.in/handle/1/839
Date: 2009


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