High resolution B Mode ultrasound of common carotid artery in evaluation of atherosclerosis in patients of rheumatoid arthritis.

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High resolution B Mode ultrasound of common carotid artery in evaluation of atherosclerosis in patients of rheumatoid arthritis.

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Title: High resolution B Mode ultrasound of common carotid artery in evaluation of atherosclerosis in patients of rheumatoid arthritis.
Author: Gupta, N (Scholar); Shah, Sonaullah (Guide); Feroze A. Shaheen (Guide)
Abstract: Research Question: Can atherosclerotic changes be detected using b mode ultrasound. (Carotid Doppler) Objectives: The aim of our study was 1) to confirm the presence of atherosclerosis in patients of rheumatoid arthritis; 2) Role of high resolution B mode ultrasound Doppler to assess the existence of atherosclerosis in RA patients, measuring the intima-medial thickness (IMT) of the common carotid arteries; and 3) Role of inflammation in development of atherosclerosis in absence of traditional risk factors. Study Design: Hospital based cross-sectional case control study. Methods: Carotid IMT was measured using high-resolution B-mode ultrasound in 40 patients with RA and 20 age- and sex-matched healthy controls. Serum total cholesterol, serum triglycerides, rheumatoid factor, body mass index (BMI) was determined. ESR, C-reactive protein (CRP) were used to measure systemic inflammation. DAS 28 was used to measure disease activity and x ray hands were used to determine erosions for bone damage. Results: Common carotid IMT were significantly higher (p=0.0000) in RA patients (0.61±0.02) compared with controls (0.45±0.07). In RA patients common carotid IMT significantly correlated with serum triglycerides (p=0.037), and ESR (p=0.034). No significant correlation was found with other clinical and laboratory parameters reflecting disease activity. Significant positive correlation was observed with use of non steroidal anti inflammatory drugs and use of ayurvedic drugs. Conclusions: Our results confirm an accelerated atherosclerosis, as shown by increased common carotid IMT, in patients with RA compared with controls even in the absence of traditional risk factors. There is definite role of inflammation in development of atherosclerosis in these patients. High-resolution B-mode ultrasound may be considered a promising, sensitive, non invasive, and cost effective tool for assessing the existence of atherosclerosis in RA patients.
URI: http://dspaces.uok.edu.in/handle/1/851
Date: 2009


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