Amelioration of Oxidative Stress in Mouse Model of Diabetic Retinopathy by Arnebia benthamii

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Amelioration of Oxidative Stress in Mouse Model of Diabetic Retinopathy by Arnebia benthamii

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Title: Amelioration of Oxidative Stress in Mouse Model of Diabetic Retinopathy by Arnebia benthamii
Author: Banday, Mujeeb Zaffar (Scholar); Ehtishamul-Haq (Guide)
Abstract: Diabetes mellitus is a chronic, multisystem heterogeneous metabolic disorder characterized by hyperglycemia which attacks both microvessels and macrovessels throughout the body resulting in the development of the specific microvascular and macrovascular complications.Diabetic retinopathy (DR), a disease of the retina, is the most common and specific microvascular complication of diabetes which remains a major cause of visual impairment worldwide among the people in working age and is a leading cause of visual loss in older patients.DR is a duration-dependent disease and both the prevalence and the incidence of retinopathy increase with increasing duration of diabetes. Diabetic retinopathy is a complex disease and the precise mechanism remains unknown. The multiple metabolic pathways have been implicated in this disease but inflammation and oxidative stress have emerged as the key players in the development of this disease. Due to this multifactorial nature the treatment of this complex disease is difficult and limited treatment options are available. The surgical procedures-laser photocoagulation and vitrectomy are currently the primary treatment options available for diabetic retinopathy. However, the use of antioxidants and antiinflammatory agents as treatment options for this disease has shown promising results in several animal studies and clinical trials. In this study, we evaluated the effect of aqueous extract of the plant Arnebia benthamii on the oxidative stress and inflammatory processes in mouse model of diabetic retinopathy. Arnebia benthamii is a traditional medicinal herb of Ayurvedic, Unani and other indigenous systems of medicine and has been known to possess antibacterial, antifungal, anti-inflammatory and wound-healing properties and also antioxidant properties. In our study and under the conditions used, we found that the aqueous extract of Arnebia benthamii instead of ameliorating the inflammation and oxidative stress associated with the disease rather further induced the pro-inflammatory and oxidative stress markers. Further study is therefore required to find if any of the individual components of the extract may be having anti-inflammatory and/or antioxidative property and or even pro-inflammatory role.
URI: http://dspaces.uok.edu.in/handle/1/912
Date: 2011


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